162 INORGANIC AGENTS 



syringe should be introduced into the jugular about midway 

 of the neck, and, after some drops of blood have exuded 

 from the vein, the syringe is attached and slowly emptied, 

 when the plunger is withdrawn until some blood enters the 

 syringe. Then the needle may be- removed with safety. 

 It is rarely necessary to repeat the dose of barium chloride, 

 and small doses of fluid extract of cannabis indica may be 

 given to lessen colic while barium is acting, when it is given 

 by the mouth. 



Extensive experiments of Muir* with barium chloride 

 lead him to conclude that the salt may be administered 

 intravenously in the amount of 1.0 to 2.0 gm. (15 to 30 gr.) 

 in 1 to 2 drachms of sterile water ; that 2 gm. is a safe dose 

 by the intrajugular method for a horse of ordinary weight 

 and fair condition ; that the drug acts promptly when given 

 in this way, catharsis being produced within one to nine 

 minutes, and that even volvulus may be relieved ; that there 

 are no unpleasant symptoms following the smaller dose 

 (1 gm.), and that even after the 2 gm. dose there are only 

 slight signs of pain and sweating ; that while the passages 

 from the bowels are few in number the total amount of 

 feces is large ; finally, that the drug has the advantage of 

 being cheap. 



That the toxic line is closely approached in giving 

 barium chloride in the dose of 2 gm. intravenously, is shown 

 by experiment 31* in which a gelding weighing 900 pounds 

 received two 2 gm. doses intrajugularly about 2f hours 

 apart, when death occurred from heart failure in nine 

 minutes after the second dose. 



* Jour, of Comp. Med. and Vet. Archives, Jan. and Feb, 1899. 



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