254 INOBGANIO AGENTS 



doses. The anesthetic action of medicinal doses is usually 

 prolonged, varying from a few hours to two or three days. 

 Orthoform has been used extensively in human medicine for 

 the past few years, and cases of poisoning have been of rare 

 occurrence and none fatal, although as much as two or 

 three ounces have been applied on ulcerated surfaces in a 

 week's time. Occasionally the drug produces an erythema 

 or dermatitis owing to peculiar susceptibility of the patient. 

 On the other hand, orthoform has been used successfully in 

 the treatment of dermatitis following ivy poisoning in th& 

 human. 



f/'ses.— Orthoform is valuable chiefly for its power in 

 relieving pain when applied to raw surfaces. It is an 

 excellent application for burns. In superficial burns, ortho- 

 form may be combined to advantage with ichthyol, of each 

 10 per cent., in lanolin. In burns of the second and third 

 degree, the use of orthoform and boric acid, equal parts, 

 forms an excellent remedy. Orthoform is serviceable in 

 relieving pain and irritation of ulcers, hemorrhoids and 

 fissures of the rectum. In human practice it is largely 

 employed in connection with diseases of the nose, ear and 

 throat to arrest pain after operations, and in ulceration and 

 inflammation of these parts, as sore throat. Nasal gleet 

 in horses should be benefited if not cured by the in- 

 sufilation of the powder. Orthoform is commonly used in 

 ointment containing 10 to 20 per cent, of the drug. It 

 may be blown pure into cavities or applied as a saturated 

 solution in collodion. It may be sprayed on a part with an 

 atomizer in 5 per cent, solution with equal parts of alcohol 

 and water. It has been injected into the bladder iu cystitis 

 mixed with water. In ulceration and other painful affec- 

 tions of the stomach, orthoform will give relief owing to its 

 local anesthetic action. It may be administered mixed with 

 water and syrup in the dose of 0.5-1.0 (7^-15 gr.) for dogs. 

 It is an expensive drug at present. 



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