SPIRIT OP GLYCERYL TRINITRATE 309 



Derivation. — Obtained tlirough distillation of nitric acid 

 and amylic alcoliol. Distillate purified by sodium carbonate. 

 HNO3 + C,H„ OH = C,H,,NO, + 2 H,0. 



Properties. — A clear, yellow or pale-yellow liquid, of a 

 peculiar ethereal, fruity (baaiana) odor, and a pungent, 

 aromatic taste. Spec. gr. 0.870 to 0.880. 



Dose (by inhalation).— H., 3 ss.-i. (2.-4.); D., niii.-v. 

 <.12-.3). 



When given internally the smaller doses should be 

 used dissolved in alcohol. 



Spibitus Glycerylis Nitratis. Spirit of Glyceryl Trinitrate, 

 Spirit of Glonoin. C3H, (N 03)3. (U. S. P.) 

 , Synonym. — Liquor trinitrini, B.P.; spiritus glonoini, 

 propenyltrinitrate, glonoin trinitrate, spirit of nitroglycerin, 

 trinitrate of glyceryl, trinitin, E. 



An alcoholic solution containing one per cent., by 

 weight, of nitroglycerin. It is probably decomposed in the 

 blood with the formation of potassium and sodium nitrite. 



Derivation. — Nitroglycerin is obtained by dropping 

 pure glycerin upon a mixture of sulphuric and nitric acids, 

 kept cool by ice, and purified by washing with water. The 

 official one per cent, solution is not explosive unless it 

 becomes concentrated by evaporation to an extent exceeding 

 10 per cent. 



Properties. — A clear, colorless liquid, possessing the 

 odor and taste of alcohol. Caution should be exercised in 

 tasting it, since even a small quantity is liable to produce a 

 violent headache. Spec. gr. .826 to .832. 



Dose.—K, 3ss.-i. (2.-4); D., nii.-ii. (.06-.12). 



ACTION OP THE NITRITES. 



Hxtemal. — Spirit of nitrous ether, like ether, prodncoa 

 a cooling and local anaesthetic action, owing to its evapora- 

 tion upon the skin. Amyl nitrite has a slight depressing 

 action upon the peripheral ends of the sensory nerves. 



Internal. — The actions of spirit of nitrous ether, amyl 



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