320 INOEGANIO AGENTS 



Derivation. — Obtained by the action of glaeifil nt^etiff 

 acid upon parapbenetitin, a phenol derivative. 



H CHaO, + C,H,0 0,H,N H = CeH.O C,H,N HC,H,0 

 + H,0. 



Properties. — Glistening, colorless, tasteless, odorless, 

 scaly crystals. Practically insoluble in water (1-925), 

 soluble in 12 jjarts of alcohol, and in glycerin, chloroform 

 and acetic acid. 



Dose.—R. & C, 3 ii.-iii- (8.-12.); D., gr.v.-x. (.3-.6). 



Antipykina. Antipyrin. C5H5 (C Hs)^ C3H NjO. 

 (U. S. P.) 



Synonym. — Phenazonum, B. P.; phenyl-dimethyl- pyra- 

 zolone. 



Z)enVa<ww.— Phenyl-hydrazine is acted upon by aceto- 

 acetic ether, when phenyl - monomethyl - pyrazolone, ethyl 

 alcohol and water result. 



H,N N H C,H, + C H3C O C H, C O O C,H, = C^H, 

 (C H3) C3H,N,0 + C,H, O H + H,0. Then C,H, (0 H,) 

 C^H^N^O + C H3 1 (methyl iodide) = C,H, (C H3), C3H N,0 

 + H I. 



Properties. — Colorless, odorless, scaly crystals, of a bit- 

 terish taste and alkaline reaction. Soluble in about its own 

 weight of water, alcohol and chloroform. 



Incompatibles. — Spirit of nitrous ether, iron sulphate, 

 chloride and iodide ; salicylates, tannin, chloral, calomel, 

 and a large number of drugs. 



i)ose.— H. & C, 3 iii--iv. (12.-15.) ; Sh. & Sw., 3 i. (4.); 

 D., gr.v.-xx. (.3-1.3). 



ACTION OF ACETANILID, ANTIPYKIN AND PHENACETIN. 



External. — Acetanilid and antipyrin are antiseptics. 

 Solutions of the latter contract vessels and exert a local 

 anesthetic and hemostatic state. 



Internal. — These substances exert no action upon the 

 digestive tract, but acetanilid possesses a decided antiseptic 

 influence upon bacteria within the alimentary canal. 



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