HEXiMETHYLENAMINE 341 



Success is reported from the use of formalin on 

 sloughing surfaces of malignant growths and foul ulcers. 

 A 4 per cent, solution is increased .'to 10 per cent, 

 and finally to pure formalin, the solutions being applied on 

 cotton saturated with the drug and retained on the part for 

 thirty minutes each day. A 5 per cent, solution of formalin 

 is serviceable for sterilizing catheters^ instruments and 

 sutures, for the preservation of pathologic specimens, for 

 the disinfection of stables, and in the treatment of canker of 

 the feet in horses. 



PREPARATIONS. 



Hexamethylenamina. Hexamethylenamine. Ce Hu N4. (IT. S. P.) 



(Urotropin.) 



Uro tropin occurs in colorless, transparent crystals, soluble in 1.8 

 parts of water and in 14 parts of alcohol; odorless, of a sweet, afterward 

 bitter taste, and slight alkaline reaction. It is made by combining solu- 

 tion^ of ammonia and formaldehyde, and was first introduced into 

 medicine by Nicolaier in 1895. Urotropin appears to be decomposed in 

 the kidneys with the liberation of formaldehyde, and thus disinfects 

 the urinary tract. It is, in fact, considered the best urinary antiseptic in 

 human medicine and has been used with the greatest success in the 

 treatment of all infectious diseases of the urinary passages, especially 

 acute and chronic pyelitis and cystitis. It renders normal a putrid 

 urine containing pus or mucus, is a solvent for uric acid and is slightly 

 diuretic. These actions should be of value in similar diseases of animals, 

 especially of dogs. The drug may be given in from 3 to 5 grain doses 

 thrice daily in solution, in canine practice. It should now be bought 

 more cheaply under its official name than by its trade name, urotropin. 

 In diabetes mellitus of the human urotropin is often beneficial in reduc- 

 ing the loss of glucose in the urine ; it should be tried in this disease in 

 dogs. 



Olutol (Formalin- Gelatin). 



Glutei is a coarse, white powder, without odor or irritating pro- 

 perties, and is prepared by dissolving gelatin in water and drying the 

 solution in formalin vapor. It is a most valuable antiseptic powder in 

 liberating formaldehyde gas in contact with living cells. Glutol forms 

 a scab when dusted over fresh wounds, preventing infection, and is 

 serviceable in the treatment of infected wounds, abscesses, boils (after 

 paracentesis), sinuses and other surgical conditions. It was first 

 brought into use by Dr. C. L. Schleich, in 1896. 



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