388 VEGETABLE DRUGS 



vegetable acids, lead ncetate and silver nitrate. Hyoscyamua 

 may be given in pill ■witb the two latter mineral salts. 

 Dose.—B.. & C. 5 ss.-i. (15.-30.); D., gr.v.-xv. (.3-1.). 



PREPARATIONS. 



Extractum Hyoscyami. Extract of Hyosoyamus. (U. S. & B. P.) 

 Made by maceration and percolation with diluted alcohol, and 



evaporation to pilular consistency. The extract should contain 0.3 per 



cent, of mydriatic alkaloids. 



Dose.— H. &C., gr.xx.-3i. (1.3-4.); D., gr.ss.-ii. (.03-.12). 



Fluidextractum Hyoscyami. Fluidextract of Hyoscyamus. 

 (U. S. P.) 



Made by maceration, percolation with alcohol and water, and 

 evaporation, so that 1 cc. = 1 gm. of hyoscyamus. Each 100 co. of 

 fluidextract contains 0.075 gm. of alkaloids from hyoscyamus. 

 Dose.— H. &C., I ss.-i. (15.-30.); D., niv.-xv. (.3-1.). 



Tinotura Hyoscyami. Tincture of Hyoscyamus. (U. S. & B. P.) 

 Hyoscyamus, 100 ; diluted alcohol to make 1000. Made by mace- 

 ration and percolation. Standardized to contain 0.007 gm. of mydriatic 

 alkaloids in each 100 cc. of the tincture. (TJ. S. P.) 

 Dose.— D., 3i.-iv. (4.-15.). 



The dose of hyoscyamus preparations is generally two to foitr 

 times that of similar belladonna preparations. 



Suocus Hyoscyami. Juice of Hyoscyamus. (B. P.) 

 Dose. — Same as tincture. 



Hyoscvamin^ Sulphas. Hyoscyamine Sulphate. 

 (C,,H,3 N O3), H,S O, 



The neutral sulphate of an alkaloid obtained from hyo- 

 scyamus. 



Derivation. — Hyoscyamine is derived from hyoscyamus 

 seed. The latter are treated with ether to extract fat, and 

 then distilled with alcohol and sulphuric acid. The liquid 

 residue is neutralized with caustic soda and precipitated 

 with tannic acid. The precipitate is mixed with lime .and 

 extracted with alcohol. The resulting alcoholic solution is 

 first treated with sulphuric acid, then with caustic soda, and 



Digitized by Microsoft® 



