402 VEGETABLE DEUGS 



*Steychnin^ Sulphas. Strychnine Sulphate. 

 (C,.H,,NA), H,S O, + 5 H,0. (U. S. & B. P.) 



Derivation. — Made by the action of sulphuric acid on 

 strychnine. 



Properties. — Colorless, or white, prismatic crystals, odor- 

 less, and having an intensely bitter taste, perceptible in 

 highly dilute (1 in 700,000) solution. Efflorescent in dry air. 

 Soluble in 50 parts of water and in 109 parts of alcohol ; 2 

 parts of boiling water and in 8.5 parts of boiling alcohol. 

 Almost insoluble in ether. Upon ignition, it is consumed, 

 leaving no residue. On adding potassium or sodium hydrate 

 to an aqueous solution of the salt, a white precipitate ia 

 thrown down, which should conform to the test for strych- 

 nine. 



Dose.—R., gr.ss.-i.ss. (.03-.09); C, gr.i.-iii. (.06-.18); Sh.» 

 gr.|-J (.015-.03); D., gr.^-^V (.0005-.0015). 



The dose of strychnine should be proportioned to the 

 weight in the case of all animals, but more particularly dogs. 

 Otherwise, convulsive attacks or a fatal result may occur. 

 The dose can be accurately determined, according to Feser, 

 by the following data : 



Dose per kilo (21bs. 3oz. 119.9gr. avoirdupois) live weight : 



Horse, sheep and cattle 0001-.0003 (gr. aSo - aSo ) 



Swine 0003-.0003 (gr.^^^) 



Dogs ■_ 0001 (gr.^) 



In accordance with the foregoing figures, dose for 



Horse weighing 1,000 lbs. is .045-.09 (gr.f-lj) 

 Dog " 100 " " .0045 (gr.^ij) 



" 50 " " .00335 (gr.A) 



" " 35 " " .00113 (gr.A) 



10 " " .00045 (gr.T;^5) 



Moreover, these doses may be given every three hours 



without producing poisoning by their cumulative action. 



Notwithstanding the foregoing figures, caution should be 



exercised in prescribing strychnine to dogs, as these animals 



* StrycJininm Nitras — Strychnine Nitrate, occurring in colorless, 

 odorless, glistening needles, is now official. Has very bitter taste; soluble 

 in 43 parts of water. Dose same as Strychnine Sulphate. StrycJininm 

 Hydrochloridum (B. P.). Dose same as Strychnine Sulphate. 



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