480 VEGETABLE DRUGS 



Derivation. — Prepared by boiling cinchona bark with 

 hydrochloric acid and adding lime to the filtered decoction 

 to precipitate alkaloids and coloring matter. The precipitate 

 is washed and digested in boiling alcohol to dissolve quinine 

 and cinchonine. The alcohol is distilled off and the residue 

 dissolved in diluted sulphuric acid, boiled with animal char- 

 coal, filtered, and quinine sulphate crystallizes, leaving 

 cinchonine sulphate in solution. 



Properties.^-'WYaie, silky, light and fine needle-shaped 

 crystals ; fragile and somewhat flexible, making a very light 

 and easily compressible mass.; lustreless from superficial 

 efflorescence after being for some time exposed to the air \ 

 odorless, and having a persistent and very bitter taste. The 

 salt is liable to lose water on exposure to warm air, to absorb 

 moisture in damp air, and to become colored by exposure to 

 light. Soluble at 15° C. (59° F.), in 740 parts of water, and 

 in 65 parts of alcohol ; in 30 parts of boiling water ; also in 

 40 parts of glycerin ; in about 680 parts of chloroform, and 

 freely in dilute acids. 



Incompatibles. — Alkalies and their carbonates, iodine, and 

 tannic acid. 



Dose. — H. (tonic), gr.xv.- 3 i. (1.-4.); C, 3ss.-i.ss. (2.-6.); 

 Sh. & Sw., gr.v.-x. (.3-.6) ; D. & Cats, gr.i.-ii. (.06-.12). Anti- 

 pyretic Dose— H. & C, 3ii.-iv. (8.-15.); Sh., gr.xxx.-xl'. 

 (2.-2.6) ; Sw., gr.xv.-'xxv. (1.-1.6) ; D. & Cats, gr.v.-x. (.3-.6). 



Quinine Bisulphas. Quinine Bisulphate. C^oHj^NjOj 

 H,SO, + 7 H,0. (U. S. & B. P.) 



Derivation. — Made by the action of sulphuric acid on 

 quinine sulphate suspended in water ; filtration and crystal- 

 lization. 



Properties. — Colorless, transparent or whitish, ortho- 

 rhombic crystals or small needles ; odorless, and having a 

 very bitter taste ; efflorescing on exposure to the air ; soluble 

 in 10 parts of cold water and in 32 parts of alcohol ; very 

 soluble in boiling water and in boiling alcohol. 4 



Dose. — Practically same as quinine sulphate, but theo- 



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