QUININE HYDEOBBOMIDE 481 



retically it should be slightly larger. The salt is very soluble, 

 but is commonly made extemporaneously by adding diluted 

 sulphuric acid (Q. S.) to quinine sulphate in preparing 

 solutions for medicinal use. The salt is serviceable for 

 administration in pill ; or for hypodermic injection, when 

 it should be given in about one-third smaller dose than that 

 of quinine sulphate by the mouth. 



Quinine Hydrobbomidum. Quinine Hydrobromide. 

 C,„H,,N,0, H Br + H,0. (U. S. P.) 



Derivation. — Made by the action of barium bromide, in 

 solution, on quinine sulphate suspended in water ; filtration, 

 evaporation, and crystallization. 



Properties. — White, light, silky needles ; odorless, and 

 having a very bitter taste. The salt is likely to lose water 

 on exposure to warm or dry air. Soluble in 54 parts of 

 cold water, and in 0.6 part of alcohol ; very soluble in 

 boiling water and boiling alcohol ; also soluble in 6 parts of 

 ether and in 12 parts of chloroform. 



Z)ose. -^Same as quinine sulphate. 



*QuiNiNiE Hydeochloeidum. Quinine Hydrochloride. 

 0,„H,,N,0, H 01 + 2 H,0. (U. S. & B. P.) 



Derivation. — Made by the action of hydrochloric acid 

 on quinine, and by crystallization. 



Properties.— White, silky, light and fine, needle-shaped 

 crystals ; odorless, and having a very bitter taste. The salt 

 is liable to lose water when exposed to warm air. Soluble 

 iu 34 parts of cold water, and in 3 parts of alcohol ; in 1 part 

 of boiling water, and very soluble in boiling alcohol ; also 

 soluble in 9 parts of chloroform. 



Dose. — Same as quinine sulphate.f 



* Tinctm-a Quinince (B. P.), from the hydrochloride. Dose— H., 

 lss.-i. D., 3ss.-i. 



t Quinince Saticylas, Quinine Salicylate (U. S. P.). Soluble in 77 

 parts of water. Occurs in colorless needles. Dose as for sulphate. 



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