574 VEGETABLE . DEUGS 



Constituents. — 1, a glucoside, frangulin (CgoHjoOio)^ 

 converted in time into (2) eniodin (C15H10O5), a glucoside, 

 to which the drug owes its purgative action. Frangulin 

 yields emodin, a constituent of rhubarb as well, and rham- 

 nose (CgHjaOg), by hydrolysis. 

 ' Dose.—B., 3 ss.-i. (2.-4.). 



PKEPAEATIONS. 



Fluidextractum Frangulce. Fluid extract of Frangula. 



Made by maceration and percolation with alcohol and water, and 

 evaporation, so that Ice. of the preparation =: 1 gm. of the crude drug. 

 Dose.—D., 3 ss.-i. (2.-4.). ' 



Ehamntts Pueshiana. (U. S. P.) 



Synonym. — Cascara Sagrada, B. P. 



Actions and Uses. — The buckthorns are laxatives in the 

 doses employed in medicine. The fresh bark of R. frangula 

 produces violent gastroenteritis- (frangulin), and the same 

 effect is produced by the bark of cascara sagrada, so that 

 both should be kept a year before using. 



Prangula is rarely employed, but Cascara sagrada is 

 probably the best purgative for chronic constipation in dogs. 

 The dose does not require to be increased on repetition. On 

 the contrary, the tone of the bowels is improved by the drug. 

 It has a very bitter taste and is apt to. cause griping so that 

 cascara is commonly given with aromatics. Fluidextractum 

 Ehamni Purshianse Aromaticum (U. S.) D. TTL xv-xxx; or 

 Syrupus Cascarje Sagradse Aromaticus (B. P.), D. 5 ss.-ii„ 

 are the best preparations. A solid and fluid extract are also 

 official (U. S. & B. P.). The aromatic syrup of c-ascara 

 sagrada may be prescribed to advantage with an ounce or 

 two of castor oil, as an occasional purgative- for dogs- A 

 syrup of purging buckthorn (Khamniis Ca-tharticus) is also 

 occasionally given dogs and cats with castor oil. D. J'-ii: 

 Cats, 5 ss-i. 



Digitized by Microsoft® 



