642 AGENTS OF ANIMAL ORIGIN 



and vagina. Adrenalin chloride is useful also in many in- 

 flammatory diseases of the eye and nose in the same strength. 

 Catarrhal conjunctivitis, keratitis, episcleritis and iritis 

 yield to its influence, particularly when it is combined with 

 other astringents on account of its transient action; with 

 atropine in iritis. Adrenalin chloride in a 1 to 5,000 solu- 

 tion containing 2 percent, of boric acid forms a useful prep- 

 aration for general application in inflammations of mucous 

 membranes. 



Internal. — Adrenalin is employed internally to arrest 

 bleeding from the stomachy intestines and uterus. Its local 

 application in hemorrhage from the bladder, rectum, nose, 

 vagina and uterus is, however, much more effective. The 

 drug is said to have yielded good results in human practice 

 in the treatment of diabetes insipidus and purpura hemor- 

 rhagica. It is not of benefit for the arrest of internal 

 hemorrhage other than in the digestive tract. This follows 

 because it does not contract the vessels of the brain and 

 lungs and because its effect in increasing general blood ten- 

 sion is inimical to its local effects in constricting vessels. 

 Keichert, as the result of his experiments on morphinized 

 dogs, believes that adrenalin is a valuable and rapidly acting 

 stimulant to the heart, vasomotor system and respiration in 

 poisoning by opiimi and ansesthetics. 



The latest experimental and clinical studies show ad- 

 renalin is of chief value for internal use in conditions of 

 greatly reduced blood pressure, as in poisoning by ether and 

 chloroform inhalation, by chloral, and in surgical shock. 

 Here it is now considered the most efficient remedy. Bossi 

 has artificially produced osteomalacia in sheep by removal of 

 one adrenal gland. Treatment has likewise been successful 

 in osteomalacia in the human, and in rickets in puppies by 

 intermuscular injection of 1-1,000 adrenalin solution 

 (m.v-xv t.i.d.). 



Administration. — Adrenalin is preferable to the so- 

 called suprarenal extracts, the dried and powdered suprarenal 

 capsules of sheep and oxen. "When the drug is given by the 

 mouth or rectum, its action on the system at large is slow 

 and tmcertain, owing to the tardiness of absorption, pre- 

 sumably due to the vascular constriction it occasions and to 



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