SEBUM THERAPY 745 



drawn over the top of the head from one auditory meatus to 

 the other. 



In most cases in veterinary practice the subcutaneous, 

 or, better, intravenous, administration will be found most 

 practicable. The dose is 5 to 20 cc; the smaller dose as a 

 prophylactic and when injected into the brain. 20 cc. is the 

 usual curative dose for the horse, although the dose may 

 vary according to the manufacturer. 



Tetanus bacilli and spores may live in the tissues for 

 weeks, and thus it is safer to repeat the dose — when given 

 for immunizing purposes— at the end of the first and third 

 week to antagonize any later intoxication caused by a new 

 crop of bacilli. 



Anti-wfectious Serum. — Antistreptococcus serum is in- 

 cluded under this head because it appears to be especially 

 antagonistic to streptococci themselves and to possess less 

 antitoxic power. In the preparation of this serum (after 

 Marmorek) streptococci are grown in human serum or 

 serous exudate mixed with two parts of peptonized bouillon, 

 and their virulence is greatly increased by repeatedly in- 

 jecting them from rabbit to rabbit. This virulence becomes 

 in this process so great that an amount of culture equivalent 

 to one single streptococcus will certainly kill a rabbit. 

 Small doses of a culture of living virulent streptococci from 

 the rabbit are injected into the horse from time to time, this 

 animal reacting vigorously to the injections. It is not until 

 the horse has undergone this treatment for a year and 

 has recovered from each injection that a serum is obtained 

 of a sufficient strength to combat living streptococci and 

 their toxins. The blood of the horse being withdrawn 

 furnishes anti-streptococcic serum. It is now thought by 

 many authorities that the serum to be most effective should 

 be polyvalent — that is, should be active against the many 

 varieties of streptococci by the cultivation of large numbers 

 of streptococci to represent their different toxins. 



•Dried antitetanlo serum has come into use and is of service as a dressing 

 in wounds which may be suspected of infection with tetanus bacilli, with an 

 eanal part of chloretone the dried serum is sold under the name otAntitetanic 

 Dusting Powder. The injection of the serum should be done, in addition to tha 

 use of dried serum on the wound . 



Digitized by Microsoft® 



