24 Harry C. Schmeisser. 
granular. (b’) Same, with two masses of chromosomes in opposite ex- 
tremes of the cell. (c’) Same, with two purple nuclei. (d’) Same, with 
three purple nuclei. 
5. Mast Cell (7): As described in normal blood. 
6. Mononuclear myelocyte with eosinophilic granules (m): Round 
or slightly elliptical, diameter about length of normal normocyte or 
longer. Nucleus, oval, pale blue with dense chromatin, eccentric. 
Cytoplasm colorless with small and large, bright red granules, some 
scattered over granules. 
Cytoplasmatic Masses without Nuclei (n).: Round or slightly oval; 
diameter varies, usually about width of normal normocyte. No nucleus. 
Cytoplasm grayish-blue, sometimes with vacuoles. 
This, then, is the blood picture common to all the leukeemic cases. 
The order of predominance of the white cells is typical of leukemia, 
differing from the normal, but agreeing with that of the spontaneous 
case. The large mononuclear is present, by far, in greatest numbers. 
The other cells of the normal blood are decreased. The polymorphonu- 
clear with eosinophilic granules and the mast cell are very scarce. The 
mononuclear myelocyte with eosinophilic granules, although not as 
common as in the spontaneous case, can usually be demonstrated in 
every leukemic animal. 
The platelets are greatly increased in number. 
Differential Count, 300 Cells. 
Per cent. 
Polymorphonuclear with eosinophilic rods.......... 6 
Polymorphonuclear with eosinophilic granules...... 0 
TSV IM PUOCY LG) sree s-csa ders oe oa Yc sree Ad Bele wade sa cdawaen 4 
Large mononuclear cell...............cccecueecuecs 86 
Mast: Cell isis aeeiaatececn avails 5 avnuele paleo eae Cae eee 1 
Mononuclear myelocyte with eosinophilic granules... 1 
Unclassified cells ........... ccc cece eee e cece a eneeee 2 
100 
AUTOPSY FINDINGS. 
The weight of the animal in every case was far below its weight before 
injection.* Two lowest weights, at autopsy, were 675 and 397 gm. 
External Appearance-—The jaundice was found at times to involve 
the skin of the entire body.t The conjunctive and buccal mucous mem- 
* Animals which remained negative invariably gained in weight. 
+ Probably this was more frequent but not recognized, except when very 
grave, because of the normal yellow tint of the skin. 
