18 Harry C. Schmeisser. 
masses of cells surrounded blood-vessels, both arteries and veins, infil- 
trating the walls of the latter and filling the lumina of both. Within 
the vessels the white blood cells were present in about equal proportion 
with the red blood cells. Between these more focal accumulations the 
myeloid cells had infiltrated in a more diffuse manner between the liver 
columns, spreading them apart. It was usually difficult to demonstrate 
the capillary wall. Hepatic cells in these locations did not suffer so 
much. Some of the above-mentioned, circumscribed infiltrations 
showed a coarse sclerosis. The same infiltrating cells were present as 
in the cervical lymph-glands, with a prevalence of the large mononu- 
clear, which was very rich in mitoses, and the mononuclear myelocyte 
with eosinophilic granules. The two types of polymorphonuclear cells 
and the premature red blood cells were present in fewer numbers. 
Spleen.—Pulp diffusely infiltrated with closely packed leukemic 
cells, which crowded the reticulum, distended the blood-vessels and 
separated and compressed the Malpighian bodies. The mononuclear 
myelocyte with eosinophilic granules, although present, was scarce. 
The large mononuclear, frequently showing mitoses, was the common 
cell. 
Heart——The intramuscular capillaries, were moderately distended 
with the large mononuclears and red blood cells, present in about equal 
proportion. The former had also infiltrated between the muscle fibers. 
The mononuclear myelocyte with eosinophilic granules was only occa- 
sionally seen, both within and without the blood-vessels. 
Inungs.—The intertubular blood-vessels, their branches which extend 
into the capillary bed, and also the capillaries, were distended with 
leukemic blood, in which the large mononuclear seemed to exceed the 
ted blood cell. Mitoses were common. Infiltration of the tissue was 
limited to two foci of myeloid cells. The one was composed principally 
of the mononuclear myelocyte with eosinophilic granules and the large 
mononuclear. Mitoses, especially of the first cell, were seen. Both 
types of polymorphs were also present. The other focus was composed 
exclusively of premature red blood cells, normoblasts and megaloblasts 
showing mitoses. 
Kidneys.—All the blood-vessels, from the largest to the capillaries of 
the glomerular tuft, were distended with the characteristic leukemic 
blood. Throughout the section there was a diffuse infiltration of 
myeloid cells, especially between the convoluted tubules. Here and 
there were foci, in some of which the mononuclear myelocyte with 
