2 Harry C. Schmeisser. 
lymphocyte” of the hen’s blood.* Allowing for flattening due to 
pressure, these cells were round or oval, with round or oval nuclei, 
mostly eccentric. The nuclear chromatin appeared granular or 
reticular. The nucleus was not infrequently pale and vesicular with 
ene or more bright chromatin bodies. The cytoplasm was present as 
a narrow rim, non-granular, and basophilic. Mitoses were common. 
Between these cells was seen a delicate reticulum. In association with 
these tumor masses were quite large collections of eosinophilic cells, 
the majority showing a single, pale, round or oval, eccentric nucleus 
and a relatively abundant cytoplasm, filled with large, round, elongated, 
or spindle-shaped oxyphilic structures. They varied greatly in size 
and shape. The lymphocytes and eosinophiles were occasionally 
seen in the capillaries, but there was “certainly no definite increase 
within the blood-vessels.” From the character of the cells, their rela- 
tion to the portal spaces and absence of the lymphemia, the condi- 
tion was regarded by Butterfield as a proliferation of periportal 
lymphadenoid tissue, and thought by him to merit the designation 
“ aleukeemic lymphadenoma.” 
Mohler had under observation five similar cases showing lymphemia 
and the same lymphadenoid condition. Mobhler’s description of two 
of his cases, as presented by Butterfield, is as follows: The process 
showed a tendency to involve several organs. In one case the liver 
and spleen were the principal seats, the lungs and intestine were 
also involved. The liver was enlarged to twice the normal size, of 
very light color and mottled. Throughout its surface and within 
its parenchyma were whitish lymphomatous deposits of varying 
diameters. A section shows the liver tissue only partly obliterated 
as a result of a filling up of the interacinous capillaries with leucocytes. 
The spleen was about the size of an ordinary blue plum. Each lung 
contained a white spherical area, the size of a pea and composed 
of hyperplastic lymphoid tissue, infiltrating white cells. In the wall 
of the large intestine, involving the lymphadenoid tissue, were round, 
slightly raised nodules. In the second case the changes were most 
marked in the kidney and spleen. The liver, intestine and heart 
were also involved. The kidneys were three or four times the normal 
size and had macroscopically very much the same appearance as the 
liver in the first case. The myocardium contained some small, whitish 
* Obviously the large mononuclear cell of the classification presented in 
this paper. 
