GENEAAL DISEASES. 325 



owner gave him to a friend. Some months afterwards he was 

 sent to me again, much wasted in flesh, with pendulous abdo- 

 men, suffering from the same disease as the pup, having a 

 quantity of serous fluid in the abdominal cavity. Treatment 

 was recommended ; but some weeks afterwards I heard from 

 the owner that the favorite and valuable old dog was dead. 

 This breed of bull-dogs is, I believe, now almost extinct ; 

 they have been bred in-and-in. 



" The examination of Jiver and heart led to the detection 

 of a very usual morbid change. The liver was dark in color, 

 speckled here and there with yellow granules. In form, the 

 gland was almost globular ; in texture it was compact, with 

 the consistency of an ordinary fatty tumor. On section the 

 cut surface was granular, and mottled with minute yellow 

 specks. A small portion of the enlarged organ was ex- 

 amined under the quarter-inch objective, and the liver-cells 

 were observed to be filled with globules of fat. In addition, 

 there was a considerable quantity of deposit of the nature of 

 tubercle. 



" The heart was also much enlarged ; the cavities of both 

 ventricles were distended with coagulated blood. The walls 

 were reduced in thickness to at least one half ; and under the 

 microscope, the fibres were seen to be in the transition state, 

 between the nucleated cell form of the foetal structure, and 

 the striated character of the fully developed muscle. Between 

 the fibres there was a deposit of granular matter, identical in 

 appearance with that observed in the liver. From the history 

 of the case, there is good reason to believe that the puppy 

 was the subject of scrofula, the result of hereditary trans- 

 mission, intensified, and probably primarily induced, by the 

 system of in-and-in breeding. The peculiar feature of the 

 case is the existence of the deposit in the liver and heart- 

 organs which are not ordinarily affected to any serious extent 

 in tuberculosis. The lungs, spleen, and kidneys were free 

 from disease."* 



» From the " Veterinarian," November, 1868. 



