GENERAL DISEASES. 327 



One of these perished three-and-a-half months after the 

 local development of the disease, but the other only died in 

 the fifth month. The successful inoculation of two horses 

 with the virus obtained from the ulcers of these dogs left no 

 doubt as to the nature of the malady, which appeared in a 

 most acute form. 



" PoUi, of Milan, has induced the disease in dogs by depos- 

 iting the virus in wounds or injecting it into the circulation. 

 The effects were always apparent, but their intensity and 

 gravity varied according to the mode of introduction. Prinz, 

 Andral, Burguiferes, Letenneur, Leblanc, Rayer, Saussier, and 

 Saint Cyr * have obtained results similar to those of Renault ; 

 Lafosse has also several times successfully inoculated ' dogs 

 with the glanders and farcy virus ; and Decroix, from the 

 result of his experiments, came to the conclusion that acute 



" * The results of inoculations practised upon seven dogs with glander 

 matter, by Saint Cyr, of the I^ons Veterinary School, are summed up as 

 follows : — 



" I. Glanders is not the exclusive appanage of solipeds. 



" 2. It can certainly be transmitted to other animals, and especially to 

 the dog, by inoculation. 



" 3. In the dog, as in the horse, it manifests itself by inflammation and 

 ulceration of the inoculated wound, swelling of the lymphatic glands in 

 its vicinity, and nasal discharge. Chancrous ulcers are, if not always, at 

 least generally absent. 



" 4. Glanders in the dog is generally remarkably benignant, and except 

 in those cases in which it has been injected into the circulation, it is per- 

 haps seldom fatal. 



" 5. Notwithstanding this marked benignity of ' canine glanders,' the 

 virus none the less preserves all its activity, and when retransmitted to the 

 horse, inevitably produces the malady in as marked a form as when passed 

 direct from horse to horse. 



" 6. Lastly, glanders in the dog, as in the horse, appears to be governed 

 by the ' law of unicity ;' for with the horse actually glandered, and the dog 

 successfully inoculated for the first time, inoculation with the most active 

 glander virus produces no effect. This conclusion, however, requires more 

 experiments to corroborate it. — ' Journal de M^d. Vet. de Lyon,' 1866, p. 

 307-" 



