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the liver. This type is designated hypertrophic sclerosis of the liver. 

 Such a liver is enlarged, dehse, increased in weight, lighter in color, 

 and when cut gives the impression of cutting fibrous tissue. In 

 other instances the proliferation of fibrous tissue occurs in the inter- 

 lobular tissue only. This newly formed fibrous tissue later contracts, 

 thus diminishing the size of the affected lobules, and therefore the 

 liver as a whole. This condition is termed atrophic sclerosis. Such a 



Fig. 27. CHBONic HEPATITIS, a Liver cell; b fibrous proliferation. 



liver usually has an irregular outline (hobnail-liver) and is smaller, 

 denser, and lighter in color than a normal liver. It is possible that 

 hypertrophic sclerosis, or the formation of new fibrous tissue through- 

 out the entire liver lobule, follows when the irritant is introduced 

 through the portal vein, and atrophic sclerosis occurs when the ir- 

 ritant is introduced through the hepatic artery. 



Symptoms. — Hepatic sclerosis has au insidious onset. Probably the 

 first evidence of the disease is digestive derangement, which later 



