Inflamation. Plogosis. Phlegmasia. 45 



So with certain microbian toxins. Introduced into the general 

 circulation they produce active congestion or inflammation in the 

 seat of colonization of the microbe from which they were derived, 

 as witnessed in the use of tuberculine or mallein. Finally the 

 chill and febrile reaction which atterids on extensive inflammation 

 is essentially a nervous phenomena in its inception and progress. 



Changes in the circulation. The usual changes in the 

 bloodvessels of the inflamed part may be thus succinctly stated : 

 I. Contraction of the capillary vessels of the affected part and 

 hastening of the current of blood through them. 2. The suc- 

 ceeding dilatation of the capillaries and the slowing of the blood 

 stream, v^hich still flows uniformly throughout the diseased tis- 

 sue. 3. The flow of blood becomes irregular, at points tardy, 

 and at others oscillating or even recoiling between the pulse beats 

 when it has been forced into a vessel already blocked by coagulum. 



4. In the still pervious vessels the red blood globules occupy the 

 centre of the vessel where the current is rapid, while the white 

 globules roll slowly along the inner surface of the walls where 

 the current is slow and become adherent to the walls and station- 

 ary, while the general current rolls on. This is a direct abstrac- 

 tion of the white globules from the circulating blood and greatly 

 favors the coagulation of the blood in the capillaries. The blood 

 plates equally collect in the periphery of the vessel and escape. 



5. The adherent white globules migrate in large numbers through 

 the capillary and venous walls into the tissues. The red globules 

 migrate to a less extent at first. 6. Small coagula form in the 

 affected capillaries, forming minute red points which cannot be 

 pressed out by the finger. 7. The red globules in the area of 

 stagnation back of these capillary emboli adhere to each other by 

 their flat surfaces and form rolls which pack into the vessel and 

 are enveloped in a fibrinous clot. 8. The liquid part of the blood 

 rapidly exudes into the tissues leaving the red globules relatively 

 much more abundant in the liquid which remains inside the ves- 

 sel. 9. The walls of the capillaries become softened and allow a 

 readier transudation of liquor sanguinous, and escape of the glob- 

 ules through the walls of the vessels. 10. The arteries leading 

 to the inflamed part have their muscular coats more rigid aud un- 

 yielding and transmit much more blood than the corresponding 

 artery leading to the healthy part. 11. The heart is equally 



