30 BACTERIOLOGY. 
In 1882, Koch published his discovery of the tubercle 
bacillus. 
The same year (1882) Pasteur published his in- 
vestigations upon ‘‘ rouget’’ or hog erysipelas. In 
this year, also, his first communication upon rabies 
appeared. 
In 1882, also, Loeffler and Schiitz discovered the 
bacillus of eilainders: 
The cholera spirillum, or ‘‘ comma bacillus, 
discovered by Koch in 1884. 
The diphtheria bacillus was discovered during the 
same year (1884) by Loeffler, though it had been ob- 
served by Klebs the year before (1883). 
Rosenbach, in 1884, by the application of Koch’s 
methods, fixed definitely the characters of the various 
micro-organisms found in the pus from acute abscesses, 
etc. 
The tetanus bacillus was also discovered in 1884 by 
Nicolaier. Carle and Rattone showed that tetanus is 
an infectious disease communicable to man by inocula- 
tion. Kitasato, in 1889, obtained the bacillus in pure 
cultures. 
In 1892, Pfeiffer and Canon independently discov- 
ered a bacillus which is believed to be the specific 
cause of influenza. ° 
In 1894, Kitasato, the Japanese bacteriologist, during 
a visit to China, discovered the bacillus of the bubonic 
plague. 
These include all the most important pathogenic 
bacteria, the discovery of which is of special interest 
to medical students and physicians. We cannot close 
this brief historical review, however, of the progress of 
our knowledge in this department of science, without 
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