274 BACTERIOLOGY. 
as the liver and peritoneum, contains large numbers 
of tubercle bacilli. If smaller doses are given the 
disease is prolonged. The peritoneum and interior or- 
gans—spleen, liver, etc.—are then filled with tubercles. 
On subcutaneous injection, for instance, into the ab- 
dominal wall, there is a thickening of the tissues about 
the point of inoculation, which breaks down in about a 
week and leaves a sluggish ulcer covered with cheesy 
material. The neighboring lymph-glands are swollen, 
and at the end of two or three weeks may attain the 
size of hazel-nuts. Soon an irregular fever is set up, 
and the animal becomes emaciated, usually dying within 
four to eight weeks. If the injected material contained 
only a small number of bacilli the wound at the point 
of inoculation may heal up and death be postponed for- 
a long time. On autopsy the lymphatic glands are 
found to have undergone cheesy degeneration; the 
spleen is very much enlarged, and throughout its sub- 
stance, which is colored dark red, are distributed masses 
of nodules. The liver is also enormously increased in | 
size, streaked brown and yellow, and the lungs are filled 
with grayish-white tubercles; but, asa rule, the kidneys 
contain no nodules. Tubercle bacilli are always found 
in the affected tissues, but the more chronic the process 
the fewer the bacilli that are apt to be present. 
Rabbits are also quite susceptible to tuberculosis, but 
considerably less so than guinea-pigs. In rabbits death 
almost invariably follows inoculations of tuberculous 
material into the anterior chamber of the eye. The 
local effects are iris-tuberculosis and cheesy degeneration 
of the pupil. The bacilli then penetrate to the neigh- 
boring lymph-glands, producing softening of these, then 
pulmonary tuberculosis, general tuberculosis, and finally 
