BACILLUS COLI COMMUNIS. 449 
the symptoms of enteritis, diarrhoea, etc., and finally 
fibro-purulent peritonitis. 
~ When subcutaneous inoculations of mice and guinea- 
pigs are made it requires the introduction of much 
larger quantities of the culture to produce infection; 
in rabbits this is followed only by abscess formation at 
the point of inoculation. Dogs and cats are similarly 
affected. 
Bazy and Guyon have succeeded in producing infec- 
tion of the bladder in animals by injection of pure 
cultures into the blood with simultaneous tying of the 
ureters; Albaran and Hallé have caused cystitis and 
pyelonephritis by direct injections into the bladder and 
ureters, the urine being artificially suppressed; Chassin 
and Roger produced angiocholitis and abscess of the 
liver in the same way. Loruelle, Fraenkel, and Bar- 
hacei, by injuring or tying the intestines and intro- 
ducing dirt into the abdominal cavity, with or without 
the simultaneous injection of cultures of the colon 
bacillus, succeeded in causing diffuse peritonitis in 
animals. Akermann produced osteomyelitis in young 
rabbits by intravenous injections of cultures. So far 
all attempts to produce experimental infection of the 
intestines by the ingestion of cultures of the colon | 
bacillus have failed to give positive results (Emmerich 
and Korkunoff). 
Certain peculiar effects have been observed by Black- 
stein and by Gilbert and Lion as the result of intra- 
venous inoculation of rabbits with pure cultures of the 
bacillus coli, which are worthy of note. The former 
of these authors found, from eight to thirty-eight days 
after injection, that the liver frequently contained 
opaque, whitish or yellowish-white spots, and streaks 
29 
