484 BACTERIOLOGY. 
fever that many investigators have suspected them to 
be the cause of this disease (Kurth, Baginsky, Roskin). - 
They are found, however, regularly in the secretion of 
healthy individuals (in 100 examinations by us we found 
them in 83, and probably could have found them in 
the others by longer search). Their presence in scarlet 
fever is most probably due to their increase in the dis- 
ordered mucous membrane. . 
The causal relation of the streptococcus to the above- 
mentioned diseases has been amply proved by inocula- 
tion experiments both in man and animals. Fehleisen 
has inoculated cultures, obtained in the first instance 
from the skin of patients with erysipelas, into patients 
in the hospital suffering from inoperable malignant 
growths—lupus, carcinoma, and sarcoma—and_ has 
obtained positive results, a typical erysipelatous in- 
flammation having developed around the point of 
inoculation after a period of incubation of from fifteen 
to sixty hours. This was attended with chilly sensa- 
tions and an elevation of temperature. Persons who 
had recently recovered from an attack of erysipelas 
proved tobe immune. These experiments were under- 
taken on the ground that malignant tumors had previ- 
ously been found to improve or entirely disappear in 
persons who had recovered from accidental erysipelas. 
‘During the last few years this fact has been therapeu- 
tically applied to the treatment of malignant tumors 
by the artificial production of erysipelas by the inocu- 
lation of pure cultures of streptococcus or of their toxic 
products, and in some cases of sarcomata, with con- 
siderable success. In carcinomata the results have 
been very slight. In this country the experimental 
work upon this subject and the actual treatment of 
