MICROCOCCUS GONORRHGZ. 527 
pus is smeared on linen, it has lived for forty-nine 
days, and dried on glass for twenty-nine days (Heiman). 
No development takes place below 25° C. or above 
39° C.; it is killed at a temperature over 42° C. 
Pathogenesis. Non-transmissible to dogs, monkeys, 
horses, and rabbits, whether inoculations be made into 
the urethral, vaginal, or congenital mucous membranes. 
According to Wertheim, purulent peritonitis, not caus- 
Fia. 70. 
Colonies of gonococci on pleuritic fluid agar. (HEIMAN.) 
ing death, is produced in certain animals by the intro- 
duction of pieces of serum-agar containing colonies of 
the gonococcus. This effect was produced constantly in 
mice, occasionally in guinea-pigs, and rarely, if ever, 
in dogs, rats, and rabbits. 
Though animal inoculations are thus followed by 
negative results, the etiological relation of the gono- 
coccus to human gonorrhea has been demonstrated 
beyond question by the infection of healthy men with 
the disease by inoculation. Thus, Bumm has produced 
