602 BACTERIOLOGY. 
brane, which characterize the disease in the horse, rarely 
result from inoculation of the guinea-pig. The process 
is often prolonged, or it remains localized on the skin. 
Guinea-pigs succumb more rapidly to intraperitoneal 
injection, usually in from eight to ten days, and in 
males the testicles are invariably affected. 
Glanders occurs as a natural infection only in horses 
and asses; the disease is occasionally communicated to 
man by contact with affected animals, and usually by 
inoculation on an abraded surface of the skin. The 
contagion may also be received on the mucous mem- 
brane. Infection has sometimes been produced in 
bacteriological laboratories. In the horse, the disease 
may be localized in the nose (glanders) or beneath the 
skin (farcy). The essential lesion is the granulomatous 
tumor, characterized by the presence of numerous lym- 
phoid and epithelioid cells, among and in which are seen 
the glanders bacilli. These nodular masses tend to break 
down rapidly, and on the mucous membrane form ulcers, 
while beneath the skin they form abscesses. The glan- 
ders nodules may also occur in the internal organs. An 
acute and chronic form of glanders may he recognized 
in man, and an acute and a chronic form of farcy. The 
disease is fatal in a large proportion of cases. It is 
transmissible also from man to man. Washer-women 
have been infected from the clothes of a patient. The 
infective material exists in the secretions of the nose, 
in the pus of glanders nodules, and sometimes in blood; 
it may occasionaly be found in the secretions of healthy 
glands, as in the urine, milk, and saliva, and also in 
the foetus of diseased animals (Bonome). From recent 
observations it appears that glanders is by no means 
an uncommon disease among horses, particularly in 
