BACILLUS ICTEROIDES. 611 
itself particularly to experimentation with this organ- 
ism. The virus should be injected into a vein. The 
lesions found after death are said to be almost identical 
with those in human yellow fever cadavers. There is 
fatty degeneration of the liver and kidneys, accompa- 
nied by acute parenchymatous nephritis. The digestive 
apparatus shows lesions of hemorrhagic gastro-enteritis. 
The bacilli are found in the blood and the organs in 
variable quantity and in a state of absolute purity; at 
times, they may be associated with the B. coli and the 
streptococcus. 
The disease may be transmitted experimentally even 
by the respiratory tract to rabbits and guinea-pigs; the 
bacteriological examination of these cases shows, at 
least, the existence of toxic processes similar with that 
which takes place in man. The toxin is obtained by 
filtering twenty to twenty-five days’ old cultures in 
broth. It withstands a temperature of 70° C., but is 
sensibly weakened by boiling. 
According to Sanarelli, infection in the human sub- 
ject does not take place by the digestive but by the 
respiratory tract; and he suggests that the common 
moulds of the atmosphere may constitute protectors of 
the bacillus icteroides. 
Sanarelli has also prepared a protective or curative 
serum for the treatment of the disease, which he calls 
“anti-amarylic serum.’? This serum has not been 
sufficiently tested as yet to form any definite conclu- 
sions as to its value; but because of its not being an 
antitoxin, it does not tend to overcome the toxins of 
yellow fever produced in the system, and depends for 
its curative and prophylactic properties upon its germi- 
cidal influence. Hence, it is argued by Sanarelli that 
