PLASMODIUM MALARLE. 629 
- The segmentation is regarded as a reproductive pro- 
cess, and these small spherical bodies are believed to 
be the spores which penetrate a new set of corpuscles, 
and so begin a new cycle of development. The pig- 
ment is discharged into the plasma, and partly taken 
up by the leucocytes. It is finally lodged chiefly in 
the spleen, liver, and lymphatic organs. The pres- 
ence of the segmenting forms is invariably associated 
with the paroxysm. On finding them in the blood it 
can be predicted with certainty that a paroxysm is 
imminent. In quotidian fever we have to deal with 
two groups of tertian (or three groups of quartan) para- 
sites, maturing on successive days; and the full-grown 
segmenting forms of to-day’s paroxysms and the half- 
grown organisms of to-morrow’s attack are to be found 
in the blood. 
(6) QuaRTAN ParRasiTsE (see Plate II.). The early 
forms within the red blood-corpuscles are amoeboid 
bodies, similar to those of tertian fever. Soon, how- 
ever, it is noticed that the pigment is different ; the 
granules are larger and blacker, and the ameboid 
movements are not so active. In their growth the 
parasites do not decolorize the corpuscles, which some- 
times have a greenish, brassy look. From the sixty- 
fourth to the seventy-second hour the amebe have 
reached their full development, occupying the greater 
portion of the affected corpuscles ; but a thin rim of 
colored stroma can usually be seen. Some of the cor- 
puscles are completely filled by the parasites. The 
cells, as a rule, appear shrunken rather than swollen. 
Even at this stage a skilled observer can usually 
recognize the quartan from the tertian organism. The 
pigment granules then collect toward the centre, and 
