PLASMODIUM MALARIA. 631 
organism rarely occupies more than about one-third of 
the.corpuscle, the stroma of which is never entirely de- 
colorized. On the contrary, it often presents a curious 
brassy-green appearance, and looks shrunken or crum- 
pled. The cycle of development of this form is rarely 
carried out entirely in the circulating blood, but the 
bodies with centrally placed pigment are not uncom- 
mon. The observations of the Italian observers seem 
to show conclusively that the segmentation takes place 
in the spleen and in the bone-marrow and internal 
organs. The length of its cycle of development has not 
been determined. Probably different groups mature at 
varying intervals of time, from twenty-four hours or 
less to forty-eight or more (Welch). The fever associ- 
ated with this organism is characterized by irregularity, 
the paroxysms are not at definite periods, and the 
pyrexia may be more or less continuous, with remissions. 
This form is associated with the severer types of the 
malaria seen in late summer and autumn—the estivo- 
autumnal fevers of Cuba, Italy, ete. 
There are several other points of interest about the 
parasites. A corpuscle containing a half-grown organism 
may suddenly rupture; the hemoglobin diffuses, and 
the pigmented parasite is set free. The parasite may 
break up into two or three portions, perhaps from 
pressure on the slide, and slight ameboid changes may 
be seen. In other instances, apparently from certain 
free extra-corpuscular organisms, the remarkable flagel- 
late form develops itself. The pigment becomes more 
central, and the granules dance with great activity. 
Suddenly, long, thread-like processes extend from the 
body of the parasite and display remarkable move- 
ments, thrashing about over the corpuscle with extra- 
