646 APPENDIX. 
recorded in cats, in all of which an experimental dysen- 
tery was produced. The lesions found are reddening 
and swelling of the intestinal mucosa, chiefly of the 
lower half of the large bowel, with here and there 
ecchymoses, small, superficial areas of necrosis, and 
shallow ulcerations. The mesenteric glands and the 
solitary lymphoid follicles are often swollen. In the 
blood-tinged mucus covering the mucous membranes 
amcebee are found in greater or less numbers. Micro- 
scopical examination of sections of the intestine shows 
that the necrosis is limited, as a rule, to the mucosa, 
aod that beneath it the submucosa is thickened and 
cedematous and its vessels engorged; there is also small- 
celled infiltration. Amcebe are found in the borders 
of the ulcers, chiefly in the follicles of Lieberkihn; 
in the base of the ulcers they rarely penetrate more 
deeply than the upper layers of the submucosa. With 
the amcebe are found many bacteria, chiefly streptococci. 
From a comparison with the lesions of amcebic dysen- 
tery in man it will be seen that while the processes in man 
and in the cat are not identical, more especially as re- 
gards the depth and extent of the ulceration, yet in many 
points the resemblance is striking. A series of control 
experiments was undertaken, by the authors quoted, 
with amcebe from the stools of healthy individuals and 
the straw-infusion amceba of Kartulis obtained in his 
culture experiments. In neither of these cases could 
an experimental dysentery be produced in any of the 
animals inoculated. They conclude that it is proper 
to designate the pathogenic amceba as the ameba dys- 
enterice (Councilman and Lafleur), and to retain the name 
ameeba coli (Lésch) for the non-pathogenic amcba of 
the normal healthy intestine. 
