RABIES. 667 
was the “simple” ten-day method. It was soon evident 
that although this method was efficacious where the 
wounds were not severe, and were confined to parts in 
which the nerve-supply was not extensively interfered 
with, it was often quite inadequate in serious cases, 
as of wounds about the face, or of wounds inflicted 
by a mad wolf, the virus of which is more active and 
the lesions made more severe than that of the rabid 
dog of the streets. In these latter cases the injec- 
tions which, in the simple treatment, are spread over 
five days are made in three days; then, on the four- 
teenth day, a fresh series of injections, or, rather, repe- 
titions, is begun, which lasts until the twenty-first day. 
This is the ‘‘ intensive method.” In the technique of 
the treatment, which is the same in both methods, a 
small portion (about 1 em.) of the desiccated cord is 
rubbed up thoroughly with about four or five times its 
bulk of bouillon until a complete emulsion is made; 
this, then, is injected by means of a syringe, holding 
several cubic centimetres, first on one side of the hypo- 
chondriac region and then on the other, the following 
day, and so on alternately, to avoid irritation. With 
the observance of thorough asepsis no local reaction to 
speak of takes place, nor are abscesses ever formed. 
The results of Pasteur’s method of protective inocula- 
tion, as recorded in the reports issued in the Annales de 
UInstitut Pasteur and those of other antirabic institutes 
in Italy, Russia, Roumania, etc., are very favorable. 
Since 1886, when the treatment was first commenced at 
the Pasteur Institute in Paris, upward of 20,000 per- 
sons bitten by rabid, or presumably rabid, animals have 
received preventive inoculations, with a mortality of 
only 0.5 of 1 per cent.’ The mortality of those bitten 
