CONTENTS. 



PAGE. 



Preface iii 



Introduction. By Leo Loeb 1 



I. Morphology of the Poison Gland of Heloderma 1.5 



A. Anatomy of the Poison Gland of Heloderma. By Henry Fox 17 



B. Structural Changes produced in the Poison Gland by Injection of 



Pilocarpine. By Henry Fox (with the collaboration of Leo Loeb) . 29 



C. Transplantation of the ^'enom Gland. Bj' Henry Fox and Leo 



Loeb 3.5 



D. Solubility of the Venom Granules. By Henry Fox and Leo Loeb 45 

 II. General Properties and Actions of the Venom of Heloderma, and Experi- 

 ments in Inmiunization. By Ehzabeth Cooke and Leo Loeb (with some 

 additional experiments by Moyer S. Fleisher) 49 



Review of the Literature 51 



Method of Collecting the Venom and Factors which influence the 



Amount of Secretion 52 



Influence of Pilocarpine on the Secretion of Venom 53 



Effect of Heat on Venom 55 



Effect of Standing in Solution on Toxicity of Venom 57 



Effect of Dialyzing 58 



Effect of Filtration 60 



Influence of the Addition of Acid to Venom Solution 61 



Effect of Roentgen Rays on Secretion of Venom Gland 61 



Effects of Venom upon Animals 62 



Condition of Mouse's Eye produced by Injection of Heloderma Venom . 64 



Anatomical Lesions produced by Injection of Venom 66 



Histological Changes produced by Injection of Venom 69 



Influence of the Method of Administration on the Toxicity of the Venom 71 

 Effect of placing Coflodion Capsules containing Venom in the Peritoneal 



Cavity 74 



Administering Fractional Doses of Venom 76 



Susceptibility of Various Species of Animals to Heloderma Venom ... 77 



Toxicity of the Organs and Excretions of Heloderma 81 



Influence of Venom on Coagulation Time of the Blood 83 



Influence of Inoculation of Pieces of Venom Gland into Mice 86 



Immunization against Heloderma Venom 88 



Protective Power of the Serum of Immunized Rabbits 90 



Precipitins in the Serum of Rabbits immunized against Heloderma 



Venom 92 



Does Blood Serum of Heloderma contain a Venom Antitoxin? 93 



Does the Injection of Venom produce a State of Anaphylaxis? 94 



III. Bacteriology of the Saliva of Heloderma Suspeotum. By D. Rivas 97 



IV. Influence of Heloderma Venom upon Blood Pressure, Diuresis, Peritoneal 



Transudate, and Intestinal Fluid. By Moyer S. FleLsher 101 



V. Effect of the Venom of Heloderma Suspectum on the Isolated Heart. By 



Thomas Stotesbury Githens 119 



VI. ExperimentalProduotionof Acute Gastric Ulcer in the Guinea-Pig. BvM. E. 



Rehfuss 125 



V 



