40 



THE VENOM OF HELODERMA. 



Experiment E. — Gland Examined Two Months after Transplantation. 



It was considered advisable to observe the changes produced in the gland 

 after a longer period of transplantation. Accordingly, on January 18, 1910, 

 we removed a piece of the right poison gland of a Heloderma and inserted it 

 into the same side of the thorax of the same animal. On March 18 the trans- 

 planted gland was removed and fixed in Kopsch fluid. Tjrpical sections 

 showed almost the entire gland to be composed of fibrous connective-tissue 

 through which were distributed numerous connective-tissue cells, mostly 

 spindle-shaped. In most cases the connective tissue of the different lobules 

 had so completely fused as to form a nearly homogeneous mass, in which it was 

 almost impossible to recognize the outlines of the original lobules, tubules, or 

 acini. Remnants of the gland were, however, present in the form of large 



Fig. 14. — Section of peripheral part of a transplanted gland removed from the thoracic region of a Heloderma one week 

 after transplantation. The nearly normal living elements of the peripheral portion and the pycnotic and 

 necrotic mass of the deeper portion are shown (Zeiss oc. 4, obj. AA). 



vesicles, similar in all essential respects to the large vesicle-like tubules de- 

 scribed under Experiment D. Some of the vesicles were close together, but 

 others were separated by broad partitions of connective tissue. The cells of 

 the vesicles were mostly rather flat, but some of them were cubical or columnar. 

 Closely associated with one group of these vesicles were several tubules 

 of normal size and approximately normal appearance. Other tubules or fol- 

 licles of small size were observed scattered through the general fibrous tissue, 

 but were few in number. A considerable part of the transplanted gland-tissue 

 at some distance from the vesicles just described was entire^' necrotic. Along 

 its edge next to the connective tissue the necrotic material was being replaced 

 by ingrowing masses of connective-tissue cells. 



