258 VENOMOUS SNAKES AND THE PHENOMENA OF THEIR VENOMS 



With p = i and K = 0.048 gm., they found the value of q, shown under 

 "q calc. I." Figure 10 shows the results graphically. The tracing is the 

 calculated values of "q," while the circle shows the observed values. It will 

 be noted, therefore, that the values derived from the experiments mentioned 

 above can be expressed according to the simple formula 



dq 

 dn 



= Kq 



With rabbits and a constant dose of venom, 0.006 gm., they obtained the 

 results shown in the last column of table 34. 



The neutralization of the hsemolytic component of crotalus venom by its 

 specific antitoxin gave the results (in grams) shown in table 35 and figure 11. 



2 4 6 8 



o Quinea-pigs weighing 430 gm. 

 a. Guinea-pigs*weighing?37o gm. 



Fig. iz. — Intraperitoneal injection. 



Table 36. 



Fig. 13. — Guinea-pigs 

 weighing 230)""' gm. 

 Subcutaneous injec- 

 tion. 



COBRA-VENOM ANTIVENIN. 



0.0005 8 m> °f this venom was i minimal lethal dose for guinea-pigs of 

 about 500 gm. The antivenin used for this purpose was very weak and 

 took about 10 c.c. to neutralize 0.003 ff°- °^ tne venom. To 0.0028 gm. of 

 the venom were 'added the amounts of antivenin indicated under n. The 

 mixtures were, as usual, incubated for 2 hours at 36 C. ; then the fractions of 

 each mixture were injected intraperitoneally into guinea-pigs. Two series 

 were undertaken with this antivenin, one with guinea-pigs of 370 and the 

 other with those of 450 grams. The second series gave the estimate re- 

 corded in the first column g^of table]^. 



