48 THE CELL DOCTRINE. 



Paget,* 80 well known from his Lectures on Surgical 

 Pathology, suggested in 1846, that a cell might arise 

 in some other way than from a nucleus, since he had 

 met morbid growths composed entirely of fibres, in 

 which not a nucleated cell was present. Most of these 

 statements are, however, reconciled by the informa- 

 tion which has since been added to our knowledge of 

 the subject. • 



MARTIN BARRY, 1840. 



It was in his first series of erabryological researches, 

 published in Part II of the " Philosophical Transac- 

 tions" of the Royal Society of London, for 1838, p. 

 310, that Dr. Martin Barry declared " that the ger- 

 minal vesicle (which he regarded as the nucleus), and 

 its contents constitute throughout the animal king- 

 dom the most primitive portion of the ovum." In his 

 second series. Part 11, 1839, in stating that the ger- 

 minal vesicle returns to the centre of the cell, post 

 coituni,he first pointed out that'the nucleus does not 

 always accompany the cell through the whole vital 

 process at the periphery (the original position accord- 

 ing to Schleiden and Schwann), but that it also passes 

 to the centre, as we now well know. Here, also, he 

 declares, but in his third series. Part II, 1840, he 

 demonstrates, that there arise in the parent vesicle, two 

 or more infant vesicles, the parent vesicle disappear- 

 ing by liquefaction. And in his third series, p. 529, 

 he says, "The germinal vesicle does not burst, or dis- 

 solve away, or become flattened, on or before the fecun- 



* Paget, Report on the Progress of Anatomy and Physiology, 

 Br. and For. Med. Rev., July, 1846. 



