THE CELL DOCTRINE. 23 



Arn9ld* (1836), Dutrochett (1837), EaspailJ (1839); 

 all except Hodgkin admitting in greater or less de- 

 gree the importance of the globule as an ultimate phys- 

 ical element ; while it is evident, also, that there 

 was much confusion in the use of terms, the words 

 globule, granule, and ynolecule,^ being often indiscrimi- 

 nately used, and the word globule sometimes used 

 to indicate what is now clearly recognized as the 

 " cell." 



1830. His views are further elaborated in his Beitiage zur Phy- 

 siologic und Anatomie. Aus der Lehre von der Gegensazen in 

 den Kraften in lebenden thierschen Korper, ein Grundriss zur 

 Physiologie und zur allgenieinen Pathologie und Therapie, 2te 

 Auflage, besonders abgcdruikt. Stuttgart, 1842. 



* Arnold, Friedreich, Lehrbuch der Phj'siologie des Menschen. 

 Erst. Thnil, Zurich, 1836. 



f Dutrochet, Memoires pour servir a I'Histoire Anatomique et 

 Physiologique des Vegetaux et des Animaux, t. ii. Atlas. Paris, 

 1837. 



J Raspail, Eechereh. sur la struct, et le developm. de la feuille et 

 du tronc, et sur la struct., etdevel. des tissus Animale, Paris, 1837. 



I The German authors of this period, and even more recent 

 times (Henle, 1841, Virchow, 1858), at least in speaking of the 

 development of histology, seem to use indiscriminately the terms 

 granule or molecule and globule, whereas they s.,v<i morphologically 

 something distinct. A globule is usually held to be a body which, 

 under the microscope, is more or less spherical in form, possessing 

 a bright centre, and dark outline, — the width of this outline being 

 directly as the difference between 'the refracting power of the 

 globule itself and that of the menstruum in which it floats. Thus, 

 the dark outline of a globule of oil floating in water is wider than 

 that of the same globule floating in glycerin. A granule or 

 molecule, on the other hand, is indeterminate in size and shape, and 

 appears as a mere dot under the highest powers of the microscope. 

 It is true that what appears as a granule under a low power, may 

 appear as a globule under a higher. 



/ 



