THB CELL DOCTRINE. 115 



The current of the red corpuscles in some of the 

 veins appeared to be confined to the centre of the 

 vessel, and not to touch the circumference, which was 

 occupied by a great ipany lymph-globules. On the 

 following morning the whole interior of the inflamed 

 vessels appeared to be lined with lymph-globules. 

 By gently altering the focus of the microscope they 

 were seen below the red current, and inany of them 

 appeared to lie exfernally to the boundary of the vessels." 



Again, page 258:* " During some of these experi- 

 ments the islets of tissue between the capillaries be- 

 came distinctly cellular, and appeared as if over- 

 spread with irregular-shaped lymph-globules." 



These various statements, while they permit the 

 inference that Addison first conceived that the col- 

 orless blood-corpuscle becomes the pus-corpuscle in 

 inflammation, do not allow us to infer that he actu- 

 ally observed its migration through the walls of 

 vessels. Indeed, he says, page 259 : " The phenomena 

 observed in the foregoing experiments corroborate 

 the views of those distinguished physiologists who 

 entertain the opinion that the capillary distribution 

 of the blood is situated in the channels of the tissue, 

 and not in vessels with a distinct membranous coat."t 



In 1846 Waller:}: more correctly appreciated this 

 migration, but it was not until Cohnheim published 

 his famous paper on " Inflammation and Suppura- 



* The Transactions of the Provincial Medical and Surgical 

 Association, vol. xi. London, 1843. 



•f- MttUer's Physiology, vol. i, p. 229. 



J London, Dublin, and Edinburgh Philosophical Magazine, 

 vol. xxix, pp. 271 and 398. 



