THE CELL DOCTRINE. 



141 



The mode of origin of this intercellular substance 

 has given rise to considerable discussion. Schwann 

 assumed that there originally existed spindle-cells, the 

 caudate corpuscles, and that out of these cells, fas- 

 ciculi of connective tissue were developed by split- 

 ting up of the body of the cell. 



Fig. 18. 



C 2 



A, BuDdle of common, wavy, connective tissue (intercellular substance) split- 

 ting at its end into fine fibrils. B, Diagram of the development of connective 

 tissue, according to Schwann, a, Spindle-shaped cell (caudate corpuscle, fibro- 

 plastic corpuscle of Lebert), with nucleus and nucleolus, d. Cleavage of the body 

 of the cell into fibrils. C, Diagram of the development of connective tissue, 

 according to Henle. a, Hyaline matrix (blastema) with nucleolated nuclei regu- 

 larly distributed through it. 6, Fibrillation of blastema (direct formation of 

 fibrils), and transformation of the nuclei into nucleus-fibres. 



Henle thought that originally there were no cells, 

 but nuclei only were developed in the blastema at 

 certain intervals, while the fibres which afterwards 

 appeared were produced by a direct fibrillation of 

 the blastema, and that while the intermediate sub- 

 stance was thus being differentiated into fibres, the 

 nuclei gradually became elongated, so as at length to 



