142 



THE CELL DOCTRINE. 



run into one another, and thus give rise to peculiar 

 longitudinal fibres {nucleus-fibres or kernfasern). 



Reichert contended that there were cells in great 

 abundance between which was deposited intercellular 

 substance, with which the membrane of the cells be- 

 came subsequently blended, reaching thus a stage in 

 which there was no longer any boundary between 

 the cells and the intermediate substance. The nuclei 

 he thought also disappeared in some instances. The 

 intercellular fibres he said were a false interpretation 

 of an optical image. 



Virchow, with Schwann and against Henle, be- 



Diagram of the development of connective tissue, according to Virchow's in- 

 vestigations. A, Earliest stage, hyaline basis (intercellular) substance, with 

 largish cells (connective tissue corpuscles) ; the latter drawn up in rows at regular 

 intervals ; at iirst, separated, spindle-shaped and simple ; at a later period, anas- 

 tomosing and branched. B, More advanced stage -, at a, the basis-substance which 

 has become striated (fibrillaced) presents a fasciculated appearance on account of 

 the cells imbedded in it in rows, the cells becoming narrower and smaller; at 6, 

 the striation of the basis-substance has disappeared under tlie influence of acetic 

 acid, and the fine and long-anastomosing fibre-cells (connective tissue corpuscles), 

 still retaining their nuclei, are seen. 



lieves that spindle-shaped cells indisputably exist, 

 and with Henle and Reichert and against Schwann, 



