Neoplasms 365 



creased development of the parenchymatous tissue are commonly 

 associated with proliferation of the connective tissue stroma. Other 

 hyperplasias develop without adequate discoverable cause, particu- 

 larly in the Viscera, of which cirrhosis of the Liver is an example. 

 Hyperplasia of visceral canals will be referred to again under 

 Strictures. 



(2) loflanimatofy Neoplasms 



(a) Simjple Granulomata. A simple granuloma is a neoplasm 

 which does not advance beyond the stage of granulation tissue and 

 generally results from a wound. Wherever there is redundant 

 granulation tissue it is probable that the excessive growth arises 

 as a result of bacterial irritation. A granuloma involving the en- 

 tire Cornea was witnessed by Beierle. 



(b) Infective Granulomata. Included under this heading are 

 the tumor-like formations produced by the agency of mi- 

 croorganisms. They are distinct from the simple granulomata in 

 that they are produced as a .rule not merely upon the surface, but 

 throughout the various tissues. In some cases they are easily to 

 be confounded macroscopically with true tumors. This is particu- 

 larly the case with Visceral tubercular lesions which often assume 

 a carcinomatous or sarcomatous appearance. At one time Pleural 

 neoplasms were regarded as cancerous in nature, but the researches 

 of Cadiot have shown the commonest form of growth in this lo- 

 cality to be of tubercular origin. Among seven thousand dogs 

 examined at the Alfort School two hundred and fifty were found 

 to be tuberculous. In twenty-seven of these animals, twenty-one 

 showed the Lungs to be aflfected, fourteen the Pleura, fourteen the 

 Bronchial and Mediastinal Glands, three the Pericardium, one the 

 Heart, thirteen the Liver, twelve the Kidneys, six the Peritoneum 

 and Omentum, four the Spleen, and two the Intestinal Wall. Tu- 

 bercles were also found in the Testes, Bladder, and Ureter. The 

 mode of infection is believed to be by ingestion of sputum of 

 phthysical persons or inhalation of finely attenuated bacilli-bearing 

 sputum or dust. Of the twenty-seven dogs six belonged to res- 

 taurateurs, in whose establishments it is not a rare thing to find 

 infectious sputum, and where sweeping distributes the virulent dust 

 in the lower strata of the atmosfifere. The above statistics agree 

 well with others recorded by Jenson who found the organs affected 



