Neoplasms 367 



rupture of the bladder. ■ In Smith & Washbourn's investigations 

 one male was mated with twelve females, eleven of which became 

 affected. A second male contracted the disease from the females 

 and conveyed it to one of the two females with which it was mated. 

 In the vaginal wall the growth resembled a raspberry, and gradu- 

 ally increased in size and extent until the whole passage was in- 

 volved. It was situated most commonly in the neighborhood of 

 the urethral orifice, but in some cases projected from the vulva. 

 Sometimes the tumors were large enough to block up the vagina. 

 Older animals suffered more particularly, and very old ones were 

 severely affected. In the penis the growth was circumscribed, one 

 about a quarter of an inch in width. The mass was lobulated, 

 slightly constricted at the base, of a pinkish or purple color, and of 

 a consistence varying between soft and firm, but never hard. On 

 section, the surface was whitish and moderately firm. In one in- 

 stance there was a secondary growth in the inguinal glands. Smith 

 and Washbourn inoculated portions of the tumors into the sub- 

 cutaneous tissue of dogs. In four, the experiment was unsuccess- 

 ful, but tumors developed in the remaining thirteen. The follow- 

 ing conclusions were reached: These tumors can be transplanted 

 from the genitals, where they generally occur, to the subcutaneous 

 tissue of other dogs. They can be transplanted from subcutaneous 

 to subcutaneous tissue in other dogs. After reaching a maximum 

 of growth they may disappear spontaneously with or without ul- 

 ceration. They may continue to increase and cause death by 

 secondary deposits forming in the viscera. If the tumor disappears, 

 the animal is subsequently immune. Some animals are naturally 

 refractory. 



(c) Organic Strictures, These are lesions of slow develop- 

 ment and may not become obstructive for a lengthened period. 

 Their origin in some cases is obscure, but they are generally re- 

 garded as resulting from a true inflammatory process having its seat 

 in the mucosa or submucosa. Stricture is occasionally seen in the 

 Intestinal Canal, particularly in the Duodenal Region, as a cir- 

 cumscribed hyperplasia. Generally, the walls are greatly thickened 

 at the point of lesion, the mucosa remaining intact. Hobday 

 has seen strictures in the Colon. The lesion has also been known 

 to follow the separation of a gangrenous intussusceptum and the 

 coalescence of the resected bowel after end-to-end anastomosis. 

 Stricture of the Urethra sometimes follows cicatrization of surgical 



