Neoplasms . 371 



were on the pleura. Histologically, these nodules were found to 

 be composed of fibro-hyaline cartilage which had commenced to 

 calcify in the center. Ramifications extended from some of the 

 nodules into the lymphatics, and these had commenced to chondrify 

 in the center, but at the periphery there were collected groups of 

 cells without intercellular substance. Nocard removed an osteo- 

 chondroma from the left inguinal mamma. A year later an anal- 

 ogous tumor had developed in the anterior left pectoral mamma, 

 which was also extirpated. In seven or eight months' time an in- 

 cessant dry, harsh cough appeared without symptoms of bronchitis 

 but with violent and rapid cardiac action. The animal was de- 

 stroyed. At the necropsy were found: small osteo-chondromata 

 in the kidneys, and a multitude of similar tumors in the parenchyma 

 of the lungs. The right pneumogastric and cardiac nerves were 

 compressed and atrophied. Generali saw a mammary chondroma 

 form secondary growths in the lungs and kidneys, and one on the 

 pons Varolii. Cadeac saw an ossifying chondroma in the neck, the 

 size of a fist. It resembled abscess, which is often seen in this 

 region. It was blistered, but continued to enlarge until respira- 

 tion became impeded. Death followed in a few days. Post mortem 

 examination showed a voluminous tumor compressing the trachea 

 and esophagus. It was formed of a number of small nodules, some 

 of which were hard and some soft. On the mucosa of the larynx 

 were small miliary tumors, and on the mucosa of the trachea, and 

 in the lungs were other nodules. Boutelle worked out the pathology 

 of one of these tumors. An encapsulated, slightly lobulated calci- 

 fying chondroma of the mamma was removed surgically in Febru- 

 ary, 1892. In August, 1894, the subject was destroyed suffering 

 from abdominal tumor. The latter was found enclosed between 

 layers of peritoneum and attached to the stomach, omentum, and 

 spleen. A small portion of detached hepatic tissue was also ad- 

 herent to it. There were other secondary growths in the lungs, 

 pancreas, and axillary and mesenteric glands. The case also pre- 

 sented another interesting feature. At the site of operation in the 

 mamma a sinus had developed, and from this had arisen a 

 small growth which was histologically a carcinoma. Following 

 is the explanation of the process by which these tumors 

 develop. In the growth of chondromata the new cartil- 



