Granular Venereal Disease of Cows 1107 



ently the iodoform treatment had proven harmful, and interfered with the 

 progress after the cases had been placed on bacillol. 



A group of 4 virgin heifers received, March 6, one gelatine capsule each, 

 containing 10% bacillol ointment, introduced deeply into the vagina. For 

 a few days they appeared to bear the ointment well, and it was repeated 

 daily. Gradually irritation appeared and increased, the discharge became 

 more conspicuous, the vulva became swollen, straining began and loss of 

 appetite occurred. On March 12, the irritation had become so marked that 

 treatment had to be suspended. In place of bacillol ointment, we used, for 

 a day or two, a o. i^ permanganate of potash solution, and on the 17th 

 changed to 5 % bacillol ointment. This could not be borne, and we again 

 used 0.1% potassium permanganate, under which the irritation abated, but 

 no marked progress was made. On April 5, two of the heifers were removed, 

 and the other 2 were changed to 0.75% bacillol. 



A 2^ year heifer, after having been served 9 times and by 5 different 

 bulls, presumably conceived, and later aborted. This conclusion was predi- 

 cated upon suspension of estrum for 4 months, after which it returned. On 

 March 6, 1909, she received an irrigation of i % carbolic acid, tannin and 

 glycerine, which caused severe straining for xyi, hours. On March 7, the 

 vulvar mucosa was much irritated. She received a 1-4000 corrosive subli- 

 mate solution, which caused severe straining. The same was repeated on 

 the 8th. March 9 she received a 2% solution of lactic acid, which caused 

 very intense straining. On March 10, she received an application of 10% 

 carbolic acid ointment, which caused some straining. This was continued 

 for 5 days. On March 15 and i5, she received 10% bacillol ointment, which 

 caused slight straining. From March 17 to April 5, she received daily a 2% 

 iodine ointment, with little straining or irritation. On April 6, she was 

 placed upon 0.75^ bacillol, since which time she has improved slowly. 



A group of 5 cows received, on March 6, vaginal injections of i % carbolic 

 acid ; all strained violently for i }i hours. As all were in somewhat advanced 

 pregnancy, it was deemed dangerous to continue so irritant an application. 



On March 7, each animal in the group received, in ihe vagina a gelatme 

 capsule containing 2 drams iodoform. This treatment was continued till 

 March 16, accompanied by little or no straining, but the irritation and dis- 

 charge did not improve. On March 17, a change was made to 5% carbolic 

 acid ointment, which caused straining and irritation. 



On March 18, a change was made to irrigations with 0.1% potassium 

 pecmanganate solution, under which there was slight, but unsatisfactory 

 improvement until April 6, when they were placed upon 0.75% bacillol 

 solution, from which date slow improvement has occurred. 



A group of 5 affected animals was placed upon daily vaginal irrigations 

 of 0.1% potassa permanganate on March 6. All seemed to do well and im- 

 proved slowly for 3 or 4 weeks, when they began to show irritation and in- 

 creased discharge, without any marked decrease in the number or size of 

 the granules in the vulva. One, well advanced in pregnancy, showed 

 signs of approaching parturition on April 7, and the vaginal irrigations 

 were suspended on April 14th. Another, also pregnant, showed increased 

 irritation, and on April 4 the potassium permanganate solution was reduced 



