26 BACTERIOLOGY. 



a disease characterized by progressive abscess forma- 

 tion, and pyaemia and septicsemia of rabbits, are among 

 the aifections produced by him in this way. It was in 

 the course of this work that the Abbe system of sub- 

 stage condensing apparatus was first used in bacteriology ; 

 that the aniline dyes suggested by Weigert were brought 

 into general use ; that the isolation and cultivation of 

 bacteria in pure culture on solid media was shown to 

 be possible ; and that animals were employed as a means 

 of obtaining pure cultures of pathogenic bacteria. 



With the bounteous harvest of original and impor- 

 tant suggestions that was reaped from Koch's classical 

 series of investigations bacteriology reached an epoch 

 in its development, and at this period modern bacteri- 

 ology may justly be said to have had its birth. 



Note. — I have presented only the most prominent 

 investigations that will serve to indicate the lines along 

 which the subject has developed. For a more detailed 

 account of the historical development of the work the 

 reader is referred to Loeffler's Vorlesungen uber die 

 gesehiehtliche Entwickelung der Lehre von den Bacteiien, 

 upon which I have drawn largely in preparing the 

 foregoing sketch. 



