OBSERVATION OF INOCULATED ANIMALS. 203 



marked and constant temperature variations until just 

 before death, when there will sometimes be a rise and 

 at other times a fall of temperature. 



In the majority of cases, however, one must be very 

 cautious as to the amount of stress laid upon changes 

 in weight and temperature, for unless they are progres- 

 sive or continuous in one or another direction they 

 may have little or no significance in indicating the 

 existence or absence of disease. 



