250 BACTERIOLOGV. 



when the infection is general, i. e , when the process is 

 of the acute miliary type. This pathological-anatomical 

 alteration is best seen in the tissues of the liver and 

 spleen of these animals, where the condition is most 

 pronounced. 



In general, the tubercular lesions can be divided into 

 those of strictly focal character — the miliary and the 

 conglomerate tubercles, and those which are more diffuse 

 in their nature. The latter lesions, although of the same 

 fundamental nature as the miliary tubercles, are much 

 greater in extent and not so sharply circumscribed. 



These latter lesions play a greater role in the path- 

 ology of the disease than do the miliary nodules, although 

 it is to the presence of the latter that the disease owes 

 its name. 



At autopsy the pathological manifestations of the 

 disease are not infrequently seen to be confined to the 

 seatof inoculation and the neighboring lymphatic glands. 

 These tissues will then present all the characteristics 

 of the tuberculous process in the stage of cheesy de- 

 generation. When the disease is general the degree 

 of its extension varies. Sometimes the small gray 

 nodules — the miliary tubercles — are only to be seen with 

 the naked eye in the tissues of the liver and spleen. 

 Again, they may invade the lungs, and commonly 

 they are distributed over the serous membranes of 

 the intestines, the lungs, the heart, and the brain. 

 These simple gray nodules, as seen by the naked eye, 

 vary in size from that of a pin-point to that of a hemp- 

 seed, and as a rule are, in this stage, the result of the 

 fusion of two or more smaller miliary foci. Though 

 the two terms, " miliary " and " conglomerate," exist 

 for the description of the macroscopic appearance of 



