398 BACTERIOLOGY. 



do, for there are no organisms i'n the blood to interfere 

 with its circulation. Our hypothesis then in regard to 

 the condition found in our first case of anthrax is again 

 not tenable. Similarly, if an animal that has died of 

 tetanus be examined we do not find the bacilli in the 

 tissues and circulating fluids generally, and, indeed, 

 often fail to find them at the point of injury. Plainly, 

 these fatal results with their accompanying tissue 

 changes occur from the presence of a something that 

 cannot be detected by either cultural or microscopic 

 methods, and this something can be only a soluble sub- 

 stance that is produced at the site of inoculation, gains 

 access to the circulation and through this channel causes 

 death, for it is hardly to be imagined that the insignifi- 

 cant wound made in the course of inoculation could 

 per se have had this effect. In other words, these latter 

 animals have died from what is called toxcemia (poison 

 in the blood), a condition conspicuously different from 

 sepiiccemia, as seen in our first animal dead of an- 

 thrax. 



There are, again, other infectious diseases, many of 

 which are known to present variations from what might 

 be considered a typical course, that may still further 

 serve to support the view that infection is a process in 

 which the mechanical effect of organisms in the cir- 

 culating fluids is of little consequence. Conspicuous 

 among these are the infections that follow upon the 

 introduction into the tissues of susceptible animals of 

 cultures of the microeocous lanceolatus (pneumococcus), 

 of the bacillus of chicken cholera, and of the organ- 

 isms concerned in the production of the so-called 

 hemorrhagic septicaemias. When running their normal 

 course these organisms cause typical septicaemias when 



