416 



THE HEMORRHAGIC DIATHESES 



Another tree of a well-marked bleeder family was described by M. Pisehei 

 in 1889 in his dissertation on this disease. This family, comprising more 

 than four generations, lived in a village in Wiirttemberg, and though otherwise 

 not of distinction was characterized by a few remarkable facts. Thus the 

 apparent male ancestor who was a bleeder (he married twice, one wife evi- 

 dently not being hemophilic, there being bleeders among the children of both 

 marriages) himself directly transmitted the predisposition, whereas this is 

 ordinarily the case only with fhe female members of the family. Further- 

 more, among the female " conductors," there were two who were themselves 

 bleeders, which is contrary to the rule. On the whole, among 114 members of 

 the family there were 17 bleeders, 13 males and 4 females, the implication of 

 the female sex being excessively high. The length of life of these bleeders 

 was from nine months up to sixty-two years. In most members of the fam- 

 ily, especially among the bleeders, there was another pathologic predisposition, 

 namely, to rheumatic afEections, headache, congestions, and affections of the 

 teeth. 



Only continuous and prolonged study of the genealogical history of a 

 bleeder family will reveal whether the disease is likely to assert itself for a 

 longer time, or whether the tendency is so diminished in the mothers of the 

 third generation that it will no longer betray itself. 



Fro. 22. — Genealogical, Tree op the Bleeder Family Mampel. (After Lessen.) 



Bleeders are shaded. 



D 



+ 



well 



GUIDE TO FIGURES 22, 23, 24, AND 25. 

 (^j female descendants 



male " 



female " 



male " 



died from hemorrhage 



bleeder 

 f Daltonist 

 J hemeralops 



