Treatment. 231 



been doubtful, as alongside of the favorable results reported by Straube, 

 Thomas, Clausen, Richter & Feuerhack, there are those of Zerler & 

 Giesenschlag as well as Gutzeit, which are unfavorable. The value of 

 the lodipin treatment as recommended by Franz, Thomas and Tantos 

 (10 g. of a 25% solution of iodipin injected daily subcutaneously, and 

 on every second day 50 g. of a 10% iodipin solution per os), cannot 

 be judged at the present time. 



Of the silver preparations Dieckerhoff recommended Crede's colloid 

 silver or CoUargol (50 g. of a freshly prepared 1% solution intra- 

 venously 2-4 times a day at the beginning of the disease) ; the results 

 from this method of treatment varied. While Thomassen, Zimmermann, 

 Roder, Dresdow, MoUerau and others obtained satisfactory results, the 

 experiences vsdth this method in the Prussian army were not so encour- 

 aging; in the years 1899-1902, 51 animals were treated, with Collargol, 

 of which 40 (78.5%) recovered, while of 35 animals which were treated 

 by other methods or were not given any treatment 26 (74.3%) recov- 

 ered. At the Budapest clinic in the years of 1898-1902 25 animals 

 received the silver treatment, and 14 (56%) recovered, while 16 other 

 cases were treated otherwise, of which 8 (50%) recovered. It was 

 observed that even when this remedy was employed at the earliest 

 stages of the disease it did not influence its normal course (Fettick). 

 Payrou declared this remedy to be worthless, and Brohle observed a 

 fatal termination in three cases as a result of embolism of the pulmonary 

 arteries following an intravenous injection of 0.4:40.0 g. Collargol. 



Conditions are similar in the case of Ichthargan (50 g. of a 1% 

 solution intravenously), as recommended by Lange and Jost. The 

 results obtained with this preparation in the Prussian army in the years 

 of 1904-1905 were not uniform. Ziirn calls attention to the hemolytic 

 and strongly irritating action of this remedy, and therefore recommends 

 only 0.1 to 0.2% solutions for intravenous injections. (Lovy saw after 

 an injection of 0.5 g. of a 1% solution, the development of severe 

 toxic symptoms in a horse of advanced age). 



Bertelotti employed spirits of turpentine (5.0 g. intravenously), 

 Howe oil of turpentine (per os), Pelz, Thomas and Feuerhack tallianin 

 (10-30 cc. intravenously), Gorjaew corrosive sublimate (10 cc. of a 1% 

 solution intravenously). Beck lastate of silver or Actol (40 cc. of a 1% 

 solution 3 times daily intravenously), apparently with good results. 



Serum Treatment. Stimulated by the good results obtained in 

 human medicine with Marmorek's anti-streptococcus serum in strepto- 

 coccus infections, various authors used the serum for the treatment of 

 purpura hemorrhagica in liorses, according to the prevailing idea that the 

 disease is also caused by a streptococcus infection. This appeared justi- 

 fied in view of Lignieres' assertion that the streptococci associated with 

 purpura hemorrhagica was identical with the pyogenic streptococci of 

 man, and in view of his good results with Marmorek's serum in mice. 

 The treatment consists of subcutaneous injections of 10-40 g. serum, 

 3 to 6 times daily, or repeated even every hour. (Sommermeyer 

 injects first 10 g. of immune serum subcutaneously and later 20 g. 

 normal serum intravenously). 



The reports published so far on the use of Marmorek's serum are 

 favorable (Lignieres, Mouilleron & Rossignol, Peuch, Pecus, Maier who 

 used in one case 190 and in another 440 g. serum inside of two weeks!), 

 as well as about the Jess-Piorkowski serum prepared in a similar way 

 (Sommermeyer, Bolz). Lignieres' results show only two deaths in 



