OAO Fo.ot-aiid-Mputli Disease. 



down continually. If they are urged to walk they move very 

 slowly, displaying much lameness, while small animals hop on 

 three, or sometimes even on two feet, or they move about on 

 their knees. 



The progressive inflammation leads finally to the formation 

 of abscesses (panaritium), which are mostly observed on the 

 coronary band above the affected interdigital space, more 

 rarely on the heels of the feet. The abscesses break outwardly 

 provided they have not been opened, or the suppurating process 

 continues to burrow into the deeper parts. This results in caries 

 or necrosis of the coronary or pedal bone, or the pus breaks into 

 the coronary or pedal joint, sometimes also into the sheaths 

 of the tendons, while in other cases the inflammatory process 

 extends along the sensitive lamina, resulting in the formation 

 of fistulas, partial loosening of the horny wall and sometimes 

 in the loss of the hoofs. 



According to Lytdin in cattle with translucent hoofs, red spots 

 may be seen in the sensitive lamina of the hoof, and the loss of the 

 hoofs, as well as the changes of the horny wall; and the horny sole, 

 in cattle and hogs, when severely affected with foot-and-mouth disease, 

 is probably associated with an affection of the matrix of the hoof. 



The affection of the udder- may lead to deep, penetrating 

 abscess formation in the affected quarter, due to the irritation 

 during milking, and to possible infection, as a result of which 

 slowly healing defects develop on the skin. Sometimes a con- 

 siderable quantity of the milk remains in the udder, and this 

 commences to decompose, through an infection originating in 

 the milk ducts, whereupon a parenchymatous inflammation of 

 the udder develops, which finally leads to atrophy of the affected 

 quarter, and sometimes also to obliterating strictures of the 

 canals of the teats. 



In severe cases septicemia or pyemia, with their well-known 

 symptoms and fatal termination may result, and if death should 

 not immediately follow the patient becomes greatly emaciated, 

 and finally succumbs to complete exhaustion. Such a termina- 

 tion may be noticed in affected animals, which although the local 

 process is not very malignant, yet have remained continuously 

 lying, because of the pain in their feet, until decubitus gangrene 

 has set in. 



In young animals acute gastro-intestinal catarrh is a very 

 frequent complication, often resulting in death. In such cases 

 the feeble and depressed animals do not suck, or only indiffer- 

 ently. The feces are fluid and fetid, the abdomen is sensitive 

 to pressure, the pulse is accelerated and wiry. The young 

 patients frequently die in from 2 to 3 days, sometimes even on 

 the first day after the appearance of the gastro-intestinal 

 infection. 



The gastro-intestinal catarrh is without a doubt produced by the 

 pathogenic action of the virus, which is swallowed with the saliva or 



