670 Streptotriehosis of Dogs. 



on the intermaxillary bone. The small soft centers contained micro- 

 organisms which were characterized by a radial structure and by 

 giving rise to destructive changes in their periphery. Their exact 

 nature was not determined. Complete recovery followed extirpation of 

 the tumors. 



An affection of a horse, described by Cuille, which developed with symptoms 

 of a distemper-lymphangitis and numerous abscesses, might possibly also belong 

 to this group. The pus foci opened spontaneously, one after the other, the creamy 

 pus contained in part small, white, transparent granules or larger yellowish masses 

 of Gram positive intertwined mycelia. Artificial cultivation was possible only in 

 the vacuum. The cultures thus obtained produced abscesses in horses as well as 

 in guinea pigs. The horse referred to showed symptoms of improvement for the 

 time, but finally died with symptoms of cachexia. A post-mortem examination was 

 not made. A similar species of streptothrix was observed by Dean in a hard nodule 

 at the commissure of the mouth of a horse. 



Carougeau described an epizootic disease of mules and horses in 

 Madagascar under the name of sporotrichosis which is characterized 

 by its chronic and unfavorable course and by the development of tumors 

 in the most varied portions of the body. These tumors are at first 

 firm, but subsequently they suppurate ; they do not involve the regional 

 lymph glands. In exceptional cases nodules and chancre-like ulcers 

 develop on the nasal mucous membranes. The purulent contents of 

 the nodules contain Gram positive mycelia with club-shaped ends, 

 vacuoles in their protoplasm and also spore-like Gram positive granules. 

 The parasite (sporotrichum equi) is easily grown on artificial media, 

 propagating by means of exospores. Horses and mules have been sue 

 cessfuUy infected with sporulating cultures. Internal treatment wit'i 

 potassium iodide has been found very effective. 



Literature. Luginger, Monh., 1904, XV. 289. — Berestneff, Aktinomykose 

 u. ihre Erreger. Diss. Moskau, 1897. — Silberschmidt, A. P., 1889. III. 841. — 

 Zschokke, Schw. A. 1903, XLIV. 303. — Cuim, Eev. vet., 1905. 816. — Dean, 

 Transact, of the Jenner Institute, 1899. II. 17. — Carougeau, J. vet., 1909. 8. 



b) Streptotriehosis of Dogs. Streptothrichosis canum. 



This disease, which has been observed only occasionally, is 

 caused by a specific form of streptothrix. It is characterized by 

 purulent inflammation of the serous meml)ranes and by sub- 

 cutaneous chronic abscesses. 



History. In 1888 Rabe demonstrated that the "granules" found 

 in some of the pleural and peritoneal exudates consisted of the inter- 

 woven mycelium of a fungus described by him under the name of 

 Cladothrix canis. Subsequently this fungus was minutely investigated 

 by Bahr (1904). 



Etiology. The virus of the disease (Streptothrix s. actino- 

 myces canis) produces long, branching filaments (Fig. 109), 

 which stain by the Gram-Weigert method and form occasional 

 club-shaped terminals in the course of their growth. 



